What is Isordil?

Isosorbide dinitrate is in a group of drugs called nitrates. Isosorbide dinitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Isordil.

Headache is the most common side effect; usually, standard headache treatments with over-the-counter pain products will relieve the pain. The headaches associated with Isordil usually subside within 2 weeks after treatment with the drug begins. Do not change your dose to avoid the headache. At a dose that eliminates headaches, the drug may not be as effective against angina.

Precaution

Severe hypotension, particularly with upright posture, may occur with even small doses of isosorbide dinitrate. This drug should therefore be used with caution in patients who may be volume depleted or who, for whatever reason, are already hypotensive. Hypotension induced by isosorbide dinitrate may be accompanied by paradoxical bradycardia and increased angina pectoris. Nitrate therapy may aggravate the angina caused by hypertrophic cardiomyopathy.

How should I take Isordil?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

If possible, try to rest or stay seated when you use this medication. Isosorbide dinitrate can cause dizziness or fainting.

If you use isosorbide dinitrate to treat an angina attack: Use the medicine at the first sign of chest pain. Place the sublingual tablet under your tongue and allow it to dissolve slowly. Do not chew or swallow it. The chewable tablet should be chewed and then held in the mouth for about 2 minutes before swallowing.

You may use additional tablets every 5 minutes, but not more than 3 tablets in 15 minutes.

Drug Interactions

Usually drug interactions occur when the effect of a particular drug is altered when it is taken with another drug or with food. Before one takes a medication for a particular ailment, the health expert should be informed of any other medications including non-prescription medications and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions.

Storage

Store at 25?°C (77?°F); excursions permitted to 15 30?°(59 - 86?°F) [see USP Controlled Room Temperature].